Characterization of The Neuronal Acetylcholine Receptor (nAChR) Alpha3alpha5beta2

Target Name: Neuronal Acetylcholine Receptor alpha3alpha5beta2 Receptor

NCBI ID: P38080

Neuronal Acetylcholine Receptor alpha3alpha5beta2 Receptor

Other Name(s): nAChR alpha3alpha5beta2

Characterization of The Neuronal Acetylcholine Receptor (nAChR) Alpha3alpha5beta2

The Neuronal Acetylcholine Receptor (nAChR) alpha3alpha5beta2 is a protein that plays a crucial role in nervous system function, and is potential drug target or biomarker. It is a transmembrane receptor that is expressed in various tissues, including the brain, heart, and skeletal muscles . Its function is to regulate the neurotransmitter acetylcholine, which is involved in the transmission of signals in the nervous system.

The nAChR alpha3alpha5beta2 receptor is composed of four subunits, each of which has a distinct function. The alpha3 subunit is the receptor extracellular domain, which contains the transmembrane portion of the receptor. The alpha5 subunit is the coiled-coil region, which is responsible for the receptor's ability to bind to neurotransmitters. The beta2 subunit is the intracellular domain, which contains the receptor's catalytic and regulatory functions.

The nAChR alpha3alpha5beta2 receptor is involved in a wide range of physiological processes in the nervous system, including the transmission of signals, neurotransmitter release, and modulation of neural activity. It is involved in the regulation of many different neurotransmitters, including acetylcholine, GABA, and nitric oxide. It is also involved in the modulation of ion channels, including the voltage-gated sodium channels (VGSA) and the calcium channels.

The nAChR alpha3alpha5beta2 receptor is a potential drug target because of its involvement in a wide range of physiological processes. Many neurotransmitters that are involved in the transmission of signals in the nervous system have been shown to interact with the nAChR alpha3alpha5beta2 receptor. This suggests that blocking This receptor may be an effective way to treat a variety of neurological and psychiatric disorders.

In addition to its potential as a drug target, the nAChR alpha3alpha5beta2 receptor is also a potential biomarker. The alpha3 subunit of the receptor is highly conserved across different species, which suggests that it may be a useful marker for tracking the progression of neurodegenerative diseases. The alpha5 subunit of the receptor is also a potential biomarker, as its function in the coiled-coil region suggests that it may be involved in the regulation of neurotransmitter release.

The nAChR alpha3alpha5beta2 receptor is also involved in the regulation of many physiological processes that are important for brain function. For example, the alpha3 subunit of the receptor has been shown to be involved in the regulation of neurotransmitter release in the hippocampus, while the alpha5 subunit has been shown to be involved in the regulation of neurotransmitter release in the prefrontal cortex.

In conclusion, the Neuronal Acetylcholine Receptor alpha3alpha5beta2 is a protein that plays a crucial role in nervous system function and is potential drug target or biomarker. Its function is to regulate the neurotransmitter acetylcholine, which is involved in the transmission of signals in the nervous system. The nAChR alpha3alpha5beta2 receptor is involved in a wide range of physiological processes in the nervous system, including the transmission of signals, neurotransmitter release, and modulation of neural activity. It is a potential drug target and biomarker, and its study may provide new insights into the underlying mechanisms of neurological and psychiatric disorders.

Protein Name: Neuronal Acetylcholine Receptor Alpha3alpha5beta2 Receptor

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